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The differential regulation of cellular mechanisms involved in vascular aging between males and females may partly explain the observed variation [67]

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For both Most Studied Pathways and Gene-Associated Pathways, the threshold of rank 30 was chosen to balance sensitivity and specificity, capturing pathways with substantial evidence while minimizing the inclusion of less relevant ones

doi: 10.1016/j.jaad.2014.03.019 140 MashalyMEKotbHMAbdinAAHedyaSE

Molecular Size Larger peptides generally contain: More peptide bonds More reactive sites Greater structural complexity This often increases the likelihood of: Hydrolysis Oxidation Aggregation Smaller peptides frequently demonstrate greater resilience after reconstitution